Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine
We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) Bowl receptor GluN2D subunit knockout (GluN2D-KO) mice.Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced de